Ontology highlight
ABSTRACT:
SUBMITTER: Murn J
PROVIDER: S-EPMC2605229 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Murn Jernej J Alibert Olivier O Wu Ning N Tendil Simon S Gidrol Xavier X
The Journal of experimental medicine 20081215 13
B cell receptor (BCR) signaling contributes to the pathogenesis of B cell malignancies, and most B cell lymphomas depend on BCR signals for survival. Identification of genes that restrain BCR-mediated proliferation is therefore an important goal toward improving the therapy of B cell lymphoma. Here, we identify Ptger4 as a negative feedback regulator of proliferation in response to BCR signals and show that its encoded EP4 receptor is a principal molecule conveying the growth-suppressive effect ...[more]