Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC2606048 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20080806 18
Microtubules are among the most successful targets of compounds potentially useful for cancer therapy. A new series of inhibitors of tubulin polymerization based on the 2-amino-3-(3,4,5-trimethoxybenzoyl)-4,5,6,7-tetrahydrothieno[b]pyridine molecular skeleton was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. The most promising compound in this series was 2-amino-3-(3,4,5-trimethoxybenzoyl)-6-methoxycarbonyl-4,5,6,7-tetrahy ...[more]