Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study.
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ABSTRACT:
SUBMITTER: Cherney DZ
PROVIDER: S-EPMC2606837 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study.
Cherney David Z I DZ Konvalinka Ana A Zinman Bernard B Diamandis Eleftherios P EP Soosaipillai Anton A Reich Heather H Lorraine Joanne J Lai Vesta V Scholey James W JW Miller Judith A JA
Diabetes care 20081022 1
<h4>Objective</h4>The aim of this study was to examine the effect of protein kinase Cbeta inhibition with ruboxistaurin on renal hemodynamic function and urinary biomarkers (monocyte chemoattractant protein-1 [MCP-1] and epidermal growth factor) in renin angiotensin system blockade-treated type 1 diabetic subjects.<h4>Research design and methods</h4>Albuminuric subjects were randomized (2:1) to ruboxistaurin (32 mg daily; n = 13) or placebo (n = 7) for 8 weeks. Renal hemodynamic function was mea ...[more]
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