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Biomimetic reliability strategies for self-healing vascular networks in engineering materials.

ABSTRACT: Self-healing via a vascular network is an active research topic, with several recent publications reporting the application and optimization of these systems. This work represents the first consideration of the probable failure modes of a self-healing system as a driver for network design. The critical failure modes of a proposed self-healing system based on a vascular network were identified via a failure modes, effects and criticality analysis and compared to those of the human circulatory system. A range of engineering and biomimetic design concepts to address these critical failure modes is suggested with minimum system mass the overall design driver for high-performance systems. Plant vasculature has been mimicked to propose a segregated network to address the risk of fluid leakage. This approach could allow a network to be segregated into six separate paths with a system mass penalty of only approximately 25%. Fluid flow interconnections that mimic the anastomoses of animal vasculatures can be used within a segregated network to balance the risk of failure by leakage and blockage. These biomimetic approaches define a design space that considers the existing published literature in the context of system reliability.

SUBMITTER: Williams HR

PROVIDER: S-EPMC2607457 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Biomimetic reliability strategies for self-healing vascular networks in engineering materials.

Williams H R HR Trask R S RS Knights A C AC Williams E R ER Bond I P IP

Journal of the Royal Society, Interface 20080701 24

Self-healing via a vascular network is an active research topic, with several recent publications reporting the application and optimization of these systems. This work represents the first consideration of the probable failure modes of a self-healing system as a driver for network design. The critical failure modes of a proposed self-healing system based on a vascular network were identified via a failure modes, effects and criticality analysis and compared to those of the human circulatory sys ...[more]

PMID: 17999947

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Project description:The mechanical behavior of soft tissue extracellular matrix is time dependent. Moreover, it evolves over time due to physiological processes as well as aging and disease. Measuring and quantifying the time-dependent mechanical behavior of soft tissues and materials pose a challenge, not only because of their labile and hydrated nature but also because of the lack of a common definition of terms and understanding of models for characterizing viscoelasticity. Here, we review the most important measurement techniques and models used to determine the viscoelastic properties of soft hydrated materials-or hydrogels-underlining the difference between viscoelastic behavior and the properties and descriptors used to quantify viscoelasticity. We then discuss the principal factors, which determine tissue viscoelasticity in vivo and summarize what we currently know about cell response to time-dependent materials, outlining fundamental factors that have to be considered when interpreting results. Particular attention is given to the relationship between the different time scales involved (mechanical, cellular and observation time scales), as well as scaling principles, all of which must be considered when designing viscoelastic materials and performing experiments for biomechanics or mechanobiology applications. From this overview, key considerations and directions for furthering insights and applications in the emergent field of cell viscoelastic mechanotransduction are provided. Impact statement Our tissues are viscoelastic: they respond to mechanical stresses and strains in a time-dependent manner. Their mechanical behavior also evolves over time due to growth, aging, remodeling and disease. Understanding cell response to time-dependent and time-evolving mechanical cues is important for a better comprehension of a wide number of pathophysiological processes and for the design of biomimetic substrates, which can be used as physiologically relevant in vitro models and in regenerative medicine applications. This review highlights the importance of a more rigorous approach toward viscoelastic material design and testing for cell mechanobiology studies, which embrace the entire spectrum of elasto- and viscotransduction.

Dataset Information

Biomimetic reliability strategies for self-healing vascular networks in engineering materials.

Publications

Biomimetic reliability strategies for self-healing vascular networks in engineering materials.

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