Ontology highlight
ABSTRACT:
SUBMITTER: Tanenbaum ME
PROVIDER: S-EPMC2609737 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Tanenbaum Marvin E ME Macůrek Libor L Galjart Niels N Medema René H RH
The EMBO journal 20081120 24
Bipolar spindle assembly critically depends on the microtubule plus-end-directed motor Eg5 that binds antiparallel microtubules and slides them in opposite directions. As such, Eg5 can produce the necessary outward force within the spindle that drives centrosome separation and inhibition of this antiparallel sliding activity results in the formation of monopolar spindles. Here, we show that upon depletion of the minus-end-directed motor dynein, or the dynein-binding protein Lis1, bipolar spindle ...[more]