Stretch-activated force shedding, force recovery, and cytoskeletal remodeling in contractile fibroblasts.

ABSTRACT: The stress fiber network within contractile fibroblasts structurally reinforces and provides tension, or "tone", to tissues such as those found in healing wounds. Stress fibers have previously been observed to polymerize in response to mechanical forces. We observed that, when stretched sufficiently, contractile fibroblasts diminished the mechanical tractions they exert on their environment through depolymerization of actin filaments then restored tissue tension and rebuilt actin stress fibers through staged Ca(++)-dependent processes. These staged Ca(++)-modulated contractions consisted of a rapid phase that ended less than a minute after stretching, a plateau of inactivity, and a final gradual phase that required several minutes to complete. Active contractile forces during recovery scal

SUBMITTER: Nekouzadeh A 

PROVIDER: S-EPMC2609955 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature