Ontology highlight
ABSTRACT:
SUBMITTER: Trost B
PROVIDER: S-EPMC2610329 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Trost Brett B Kanduc Darja D Kusalik Anthony A
Journal of the Royal Society, Interface 20090101 30
There is some evidence to suggest that peptide segments that are found rarely or never in the host proteome play a role in the immune response to disease-related proteins, both those derived from microbes and those derived from the host itself. We conjecture that this pattern may extend to human proto-oncoproteins. Our hypothesis in this study is that the frequency of rare peptide segments in sets of human proto-oncoproteins is significantly higher than in sets of control proteins, and we show t ...[more]