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Rare peptide segments are found significantly more often in proto-oncoproteins than control proteins: implications for immunology and oncology.

ABSTRACT: There is some evidence to suggest that peptide segments that are found rarely or never in the host proteome play a role in the immune response to disease-related proteins, both those derived from microbes and those derived from the host itself. We conjecture that this pattern may extend to human proto-oncoproteins. Our hypothesis in this study is that the frequency of rare peptide segments in sets of human proto-oncoproteins is significantly higher than in sets of control proteins, and we show that this is the case. Possible immunological implications of this observation are discussed.

SUBMITTER: Trost B

PROVIDER: S-EPMC2610329 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Rare peptide segments are found significantly more often in proto-oncoproteins than control proteins: implications for immunology and oncology.

Trost Brett B Kanduc Darja D Kusalik Anthony A

Journal of the Royal Society, Interface 20090101 30

There is some evidence to suggest that peptide segments that are found rarely or never in the host proteome play a role in the immune response to disease-related proteins, both those derived from microbes and those derived from the host itself. We conjecture that this pattern may extend to human proto-oncoproteins. Our hypothesis in this study is that the frequency of rare peptide segments in sets of human proto-oncoproteins is significantly higher than in sets of control proteins, and we show t ...[more]

PMID: 18948250

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