Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2610858 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
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Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.
Liu Jieying J Bolstad David B DB Smith Adrienne E AE Priestley Nigel D ND Wright Dennis L DL Anderson Amy C AC
Chemistry & biology 20080901 9
Candida glabrata is a lethal fungal pathogen resistant to many antifungal agents and has emerged as a critical target for drug discovery. Over the past several years, we have been developing a class of propargyl-linked antifolates as antimicrobials and hypothesized that these compounds could be effective inhibitors of dihydrofolate reductase (DHFR) from C. glabrata. We initially screened a small collection of these inhibitors and found modest levels of potency. Subsequently, we determined the cr ...[more]
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