Elevated cytokine expression in the orbitofrontal cortex of victims of suicide.
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ABSTRACT:
SUBMITTER: Tonelli LH
PROVIDER: S-EPMC2612100 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
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Elevated cytokine expression in the orbitofrontal cortex of victims of suicide.
Tonelli L H LH Stiller J J Rujescu D D Giegling I I Schneider B B Maurer K K Schnabel A A Möller H-J HJ Chen H H HH Postolache T T TT
Acta psychiatrica Scandinavica 20071213 3
<h4>Objective</h4>Based on the reported association between cytokines with depression and suicide, and evidence of increased markers of inflammation in the brain of suicide victims, the present study examined the expression of cytokines in the orbitofrontal cortex of suicide victims.<h4>Method</h4>In a postmortem sample obtained from the Brodman area 11 of suicides (n = 34) and controls (n = 17), real-time RT-PCR was used to compare the expression of mRNA species for tumor necrosis factor-alpha ...[more]
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