Ontology highlight
ABSTRACT:
SUBMITTER: Chan EY
PROVIDER: S-EPMC2612494 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Chan Edmond Y W EY Longatti Andrea A McKnight Nicole C NC Tooze Sharon A SA
Molecular and cellular biology 20081020 1
The yeast Atg1 serine/threonine protein kinase and its mammalian homologs ULK1 and ULK2 play critical roles during the activation of autophagy. Previous studies have demonstrated that the conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Here, we explored the role of kinase activity and intramolecular interactions to further understand ULK function. We demonstrate that the dominant-negative activity of kinase-dead mutants requires a 7-res ...[more]