Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi M
PROVIDER: S-EPMC2612520 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Kobayashi Makoto M Li Li L Iwamoto Noriko N Nakajima-Takagi Yaeko Y Kaneko Hiroshi H Nakayama Yuko Y Eguchi Masami M Wada Yoshiko Y Kumagai Yoshito Y Yamamoto Masayuki M
Molecular and cellular biology 20081110 2
Animals have evolved defense systems for surviving in a chemically diverse environment. Such systems should demonstrate plasticity, such as adaptive immunity, enabling a response to even unknown chemicals. The antioxidant transcription factor Nrf2 is activated in response to various electrophiles and induces cytoprotective enzymes that detoxify them. We report here the discovery of a multiple sensing mechanism for Nrf2 activation using zebrafish and 11 Nrf2-activating compounds. First, we showed ...[more]