Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC2612541 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Lee Junghee J Kim Chun-Hyung CH Simon David K DK Aminova Lyaylya R LR Andreyev Alexander Y AY Kushnareva Yulia E YE Murphy Anne N AN Lonze Bonnie E BE Kim Kwang-Soo KS Ginty David D DD Ferrante Robert J RJ Ryu Hoon H Ratan Rajiv R RR
The Journal of biological chemistry 20051005 49
Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established. Here we report that CREB is present in the mitochondrial matrix of neurons and that it binds directly to cyclic AMP response elements (CREs) found within the mitochondrial genome. Disruption of CREB activity in the mitochondria decreases the expression of a subset of mitochondrial genes, including the ND5 subunit of complex I, down-regulates com ...[more]