Ontology highlight
ABSTRACT:
SUBMITTER: Romeo S
PROVIDER: S-EPMC2613476 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Romeo Stefano S Yin Wu W Kozlitina Julia J Pennacchio Len A LA Boerwinkle Eric E Hobbs Helen H HH Cohen Jonathan C JC
The Journal of clinical investigation 20081215 1
The relative activity of lipoprotein lipase (LPL) in different tissues controls the partitioning of lipoprotein-derived fatty acids between sites of fat storage (adipose tissue) and oxidation (heart and skeletal muscle). Here we used a reverse genetic strategy to test the hypothesis that 4 angiopoietin-like proteins (ANGPTL3, -4, -5, and -6) play key roles in triglyceride (TG) metabolism in humans. We re-sequenced the coding regions of the genes encoding these proteins and identified multiple ra ...[more]