Draft genome of the filarial nematode parasite Brugia malayi.
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ABSTRACT:
SUBMITTER: Ghedin E
PROVIDER: S-EPMC2613796 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Draft genome of the filarial nematode parasite Brugia malayi.
Ghedin Elodie E Wang Shiliang S Spiro David D Caler Elisabet E Zhao Qi Q Crabtree Jonathan J Allen Jonathan E JE Delcher Arthur L AL Guiliano David B DB Miranda-Saavedra Diego D Angiuoli Samuel V SV Creasy Todd T Amedeo Paolo P Haas Brian B El-Sayed Najib M NM Wortman Jennifer R JR Feldblyum Tamara T Tallon Luke L Schatz Michael M Shumway Martin M Koo Hean H Salzberg Steven L SL Schobel Seth S Pertea Mihaela M Pop Mihai M White Owen O Barton Geoffrey J GJ Carlow Clotilde K S CK Crawford Michael J MJ Daub Jennifer J Dimmic Matthew W MW Estes Chris F CF Foster Jeremy M JM Ganatra Mehul M Gregory William F WF Johnson Nicholas M NM Jin Jinming J Komuniecki Richard R Korf Ian I Kumar Sanjay S Laney Sandra S Li Ben-Wen BW Li Wen W Lindblom Tim H TH Lustigman Sara S Ma Dong D Maina Claude V CV Martin David M A DM McCarter James P JP McReynolds Larry L Mitreva Makedonka M Nutman Thomas B TB Parkinson John J Peregrín-Alvarez José M JM Poole Catherine C Ren Qinghu Q Saunders Lori L Sluder Ann E AE Smith Katherine K Stanke Mario M Unnasch Thomas R TR Ware Jenna J Wei Aguan D AD Weil Gary G Williams Deryck J DJ Zhang Yinhua Y Williams Steven A SA Fraser-Liggett Claire C Slatko Barton B Blaxter Mark L ML Scott Alan L AL
Science (New York, N.Y.) 20070901 5845
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny ...[more]
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