Ontology highlight
ABSTRACT:
SUBMITTER: Wedren S
PROVIDER: S-EPMC2613912 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
BMC cancer 20081106
<h4>Background</h4>Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk.<h4>Methods</h4>In 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five markers in ESR1 and used logistic regression models to estimate odds ratios (OR) and 95 percent confidenc ...[more]