Ontology highlight
ABSTRACT:
SUBMITTER: Iwashita T
PROVIDER: S-EPMC2614078 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Iwashita Toshihide T Kruger Genevieve M GM Pardal Ricardo R Kiel Mark J MJ Morrison Sean J SJ
Science (New York, N.Y.) 20030801 5635
Genes associated with Hirschsprung disease, a failure to form enteric ganglia in the hindgut, were highly up-regulated in gut neural crest stem cells relative to whole-fetus RNA. One of these genes, the glial cell line-derived neurotrophic factor (GDNF) receptor Ret, was necessary for neural crest stem cell migration in the gut. GDNF promoted the migration of neural crest stem cells in culture but did not affect their survival or proliferation. Gene expression profiling, combined with reverse ge ...[more]