Ontology highlight
ABSTRACT:
SUBMITTER: Lightfield KL
PROVIDER: S-EPMC2614210 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Nature immunology 20080824 10
Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. To further elucidate the host flagellin-sensing pathway, we generated mice deficient in the intracell ...[more]