Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC2614271 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Li Fei F Huarte Maite M Zaratiegui Mikel M Vaughn Matthew W MW Shi Yang Y Martienssen Rob R Cande W Zacheus WZ
Cell 20081001 2
In most eukaryotes, histone methylation patterns regulate chromatin architecture and function: methylation of histone H3 lysine-9 (H3K9) demarcates heterochromatin, whereas H3K4 methylation demarcates euchromatin. We show here that the S. pombe JmjC-domain protein Lid2 is a trimethyl H3K4 demethylase responsible for H3K4 hypomethylation in heterochromatin. Lid2 interacts with the histone lysine-9 methyltransferase, Clr4, through the Dos1/Clr8-Rik1 complex, which also functions in the RNA interfe ...[more]