Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response.
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ABSTRACT:
SUBMITTER: Adler-Wailes DC
PROVIDER: S-EPMC2614385 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
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Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response.
Adler-Wailes Diane C DC Guiney Evan L EL Koo Jashin J Yanovski Jack A JA
Obesity (Silver Spring, Md.) 20080717 10
To understand the molecular mechanisms underlying the development of dyslipidemia and lipodystrophy that occurs after administration of aspartic acid protease inhibitors, we examined transcriptional profiles using cDNA microarrays in 3T3-L1 adipocytes exposed to 10 micromol/l ritonavir for 2-21 days. The expression levels of approximately 12,000 transcripts were assessed using the MgU74Av2 mouse microarray chip. Ritonavir altered gene expression of inflammatory cytokines, stress response genes l ...[more]
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