Dataset Information

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

ABSTRACT: As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.

SUBMITTER: Kao WH

PROVIDER: S-EPMC2614692 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature

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MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

Kao W H Linda WH Klag Michael J MJ Meoni Lucy A LA Reich David D Berthier-Schaad Yvette Y Li Man M Coresh Josef J Patterson Nick N Tandon Arti A Powe Neil R NR Fink Nancy E NE Sadler John H JH Weir Matthew R MR Abboud Hanna E HE Adler Sharon G SG Divers Jasmin J Iyengar Sudha K SK Freedman Barry I BI Kimmel Paul L PL Knowler William C WC Kohn Orly F OF Kramp Kristopher K Leehey David J DJ Nicholas Susanne B SB Pahl Madeleine V MV Schelling Jeffrey R JR Sedor John R JR Thornley-Brown Denyse D Winkler Cheryl A CA Smith Michael W MW Parekh Rulan S RS

Nature genetics 20080914 10

As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. E ...[more]

PMID: 18794854

Dataset Information

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

Publications

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

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