Ontology highlight
ABSTRACT:
SUBMITTER: Colussi C
PROVIDER: S-EPMC2614736 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Colussi Claudia C Mozzetta Chiara C Gurtner Aymone A Illi Barbara B Rosati Jessica J Straino Stefania S Ragone Gianluca G Pescatori Mario M Zaccagnini Germana G Antonini Annalisa A Minetti Giulia G Martelli Fabio F Piaggio Giulia G Gallinari Paola P Steinkuhler Christian C Clementi Emilio E Dell'Aversana Carmela C Altucci Lucia L Mai Antonello A Capogrossi Maurizio C MC Puri Pier Lorenzo PL Gaetano Carlo C
Proceedings of the National Academy of Sciences of the United States of America 20081201 49
The overlapping histological and biochemical features underlying the beneficial effect of deacetylase inhibitors and NO donors in dystrophic muscles suggest an unanticipated molecular link among dystrophin, NO signaling, and the histone deacetylases (HDACs). Higher global deacetylase activity and selective increased expression of the class I histone deacetylase HDAC2 were detected in muscles of dystrophin-deficient MDX mice. In vitro and in vivo siRNA-mediated down-regulation of HDAC2 in dystrop ...[more]