Ontology highlight
ABSTRACT:
SUBMITTER: Bailey LJ
PROVIDER: S-EPMC2614738 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Bailey Lucas J LJ McCoy Jason G JG Phillips George N GN Fox Brian G BG
Proceedings of the National Academy of Sciences of the United States of America 20081125 49
Carboxylate-bridged diiron hydroxylases are multicomponent enzyme complexes responsible for the catabolism of a wide range of hydrocarbons and as such have drawn attention for their mechanism of action and potential uses in bioremediation and enzymatic synthesis. These enzyme complexes use a small molecular weight effector protein to modulate the function of the hydroxylase. However, the origin of these functional changes is poorly understood. Here, we report the structures of the biologically r ...[more]