Ontology highlight
ABSTRACT:
SUBMITTER: Flores-Borja F
PROVIDER: S-EPMC2614772 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Flores-Borja Fabian F Jury Elizabeth C EC Mauri Claudia C Ehrenstein Michael R MR
Proceedings of the National Academy of Sciences of the United States of America 20081126 49
The ultimate goal for the treatment of autoimmunity is to restore immunological tolerance. Regulatory T cells (Treg) play a central role in immune tolerance, and Treg functional abnormalities have been identified in different autoimmune diseases, including rheumatoid arthritis (RA). We have previously shown that natural Treg from RA patients are competent at suppressing responder T cell proliferation but not cytokine production. Here, we explore the hypothesis that this Treg defect in RA is link ...[more]