Mechanism of extradiol aromatic ring-cleaving dioxygenases.
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ABSTRACT:
SUBMITTER: Lipscomb JD
PROVIDER: S-EPMC2614828 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Mechanism of extradiol aromatic ring-cleaving dioxygenases.
Current opinion in structural biology 20081125 6
The extradiol aromatic ring-cleaving dioxygenases activate molecular oxygen by binding both O(2) and the catecholic substrate to a reduced active site metal, generally Fe(II). Progress has been made in understanding the mechanism of this reaction through the combined use of kinetic, computational, biomimetic, structural, and diagnostic chemical approaches. It appears that O(2) is activated by accepting an electron transferred from the substrate through the metal, thereby simultaneously activatin ...[more]
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