Ontology highlight
ABSTRACT:
SUBMITTER: Lin JH
PROVIDER: S-EPMC2614882 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Lin Jonathan H JH Li Han H Zhang Yuhong Y Ron David D Walter Peter P
PloS one 20090112 1
Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling promotes cell survival by reducing misfolded protein levels. If homeostasis cannot be restored, UPR signaling promotes cell death. The molecular basis for the switch between prosurvival and proapoptotic UPR function is poorly understood. The ER-resident proteins, PERK and IRE1, control two key UPR signaling pathways. Prot ...[more]