Ontology highlight
ABSTRACT:
SUBMITTER: Alam A
PROVIDER: S-EPMC2615071 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20081221 1
Here we present a detailed characterization of ion binding in the NaK pore using the high-resolution structures of NaK in complex with various cations. These structures reveal four ion binding sites with similar chemical environments but vastly different ion preference. The most nonselective of all is site 3, which is formed exclusively by backbone carbonyl oxygen atoms and resides deep within the selectivity filter. Additionally, four water molecules in combination with four backbone carbonyl o ...[more]