Ontology highlight
ABSTRACT:
SUBMITTER: Clerc S
PROVIDER: S-EPMC2615083 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Clerc Simone S Hirsch Christian C Oggier Daniela Maria DM Deprez Paola P Jakob Claude C Sommer Thomas T Aebi Markus M
The Journal of cell biology 20090105 1
To maintain protein homeostasis in secretory compartments, eukaryotic cells harbor a quality control system that monitors protein folding and protein complex assembly in the endoplasmic reticulum (ER). Proteins that do not fold properly or integrate into cognate complexes are degraded by ER-associated degradation (ERAD) involving retrotranslocation to the cytoplasm and proteasomal peptide hydrolysis. N-linked glycans are essential in glycoprotein ERAD; the covalent oligosaccharide structure is u ...[more]