Ontology highlight
ABSTRACT:
SUBMITTER: Deane JE
PROVIDER: S-EPMC2615192 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Deane Janet E JE Graham Stephen C SC Mitchell Edward P EP Flot David D Johnson Steven S Lea Susan M SM
Molecular microbiology 20080515 1
The pathogenic bacterium Shigella flexneri uses a type III secretion system to inject virulence factors from the bacterial cytosol directly into host cells. The machinery that identifies secretion substrates and controls the export of extracellular components and effector proteins consists of several inner-membrane and cytoplasmic proteins. One of the inner membrane components, Spa40, belongs to a family of proteins proposed to regulate the switching of substrate specificity of the export appara ...[more]