Ontology highlight
ABSTRACT:
SUBMITTER: Zhou R
PROVIDER: S-EPMC2615197 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20081101 4
The specificity of RNAi pathways is determined by several classes of small RNAs, which include siRNAs, piRNAs, endo-siRNAs, and microRNAs (miRNAs). These small RNAs are invariably incorporated into large Argonaute (Ago)-containing effector complexes known as RNA-induced silencing complexes (RISCs), which they guide to silencing targets. Both genetic and biochemical strategies have yielded conserved molecular components of small RNA biogenesis and effector machineries. However, given the complexi ...[more]