Ontology highlight
ABSTRACT:
SUBMITTER: Frankel BA
PROVIDER: S-EPMC2615482 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Frankel Brenda A BA Blanchard John S JS
Archives of biochemistry and biophysics 20080525 2
Mycobactin acylation plays a crucial role in the ability of Mycobacterium tuberculosis to acquire intracellular iron during infection. M. tuberculosis Rv1347c, the lysine N(epsilon)-acyltransferase responsible for mycobactin acylation, represents a valid target for the development of novel anti-tubercular agents. Here we investigate the substrate specificity of Rv1347c, evaluate its kinetic mechanism and probe the contributions of active-site residues to catalysis. Our results confirm that Rv134 ...[more]