Ontology highlight
ABSTRACT:
SUBMITTER: Woo KC
PROVIDER: S-EPMC2615616 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Woo Kyung-Chul KC Kim Tae-Don TD Lee Kyung-Ha KH Kim Do-Yeon DY Kim Wanil W Lee Kyung-Yeol KY Kim Kyong-Tai KT
Nucleic acids research 20081114 1
Circadian mRNA oscillations are the main feature of core clock genes. Among them, period 2 is a key component in negative-feedback regulation, showing robust diurnal oscillations. Moreover, period 2 has been found to have a physiological role in the cell cycle or the tumor suppression. The present study reports that 3'-untranslated region (UTR)-dependent mRNA decay is involved in the regulation of circadian oscillation of period 2 mRNA. Within the mper2 3'UTR, both the CU-rich region and polypyr ...[more]