Ontology highlight
ABSTRACT:
SUBMITTER: Garcia BA
PROVIDER: S-EPMC2615678 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Garcia Benjamin A BA Thomas C Eric CE Kelleher Neil L NL Mizzen Craig A CA
Journal of proteome research 20080814 10
Analyses of histone H3 from 10 rat tissues using a Middle Down proteomics platform revealed tissue-specific differences in their expression and global PTM abundance. ESI/FTMS with electron capture dissociation showed that, in general, these proteins were hypomodified in heart, liver and testes. H3.3 was hypermodified compared to H3.2 in some, but not all tissues. In addition, a novel rat testes-specific H3 protein was identified with this approach. ...[more]