Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women.

ABSTRACT:

Background

Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the SHBG gene on serum SHBG, bone mineral density (BMD), and osteoporotic fractures.

Methods

Four biallelic polymorphisms of the SHBG gene were studied by means of Taqman assays in 753 postmenopausal women. BMD was measured by DXA and serum SHBG was measured by ELISA.

Results

Age, body weight, and two polymorphisms of the SHBG gene (rs6257 and rs1799941 [A/G]) were significantly associated with serum SHBG in unadjusted and age- and weight-adjusted models. Alleles at the rs1799941 locus showed the s

SUBMITTER: Riancho JA 

PROVIDER: S-EPMC2615755 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature