Recombinant canine coronaviruses related to transmissible gastroenteritis virus of Swine are circulating in dogs.

ABSTRACT: Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.

SUBMITTER: Decaro N 

PROVIDER: S-EPMC2620906 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature