Ontology highlight
ABSTRACT:
SUBMITTER: Rauch TA
PROVIDER: S-EPMC2621253 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Rauch Tibor A TA Wu Xiwei X Zhong Xueyan X Riggs Arthur D AD Pfeifer Gerd P GP
Proceedings of the National Academy of Sciences of the United States of America 20090112 3
Using a methylated-DNA enrichment technique (methylated CpG island recovery assay, MIRA) in combination with whole-genome tiling arrays, we have characterized by MIRA-chip the entire B cell "methylome" of an individual human at 100-bp resolution. We find that at the chromosome level high CpG methylation density is correlated with subtelomeric regions and Giemsa-light bands (R bands). The majority of the most highly methylated regions that could be identified on the tiling arrays were associated ...[more]