Barcodes for genomes and applications.

ABSTRACT:

Background

Each genome has a stable distribution of the combined frequency for each k-mer and its reverse complement measured in sequence fragments as short as 1000 bps across the whole genome, for 1ResultsWe found that for each genome, the majority of its short sequence fragments have highly similar barcodes while sequence fragments with different barcodes typically correspond to genes that are horizontally transferred or highly expressed. This observation has led to new and more effective ways for addressing two challenging problems: metagenome binning problem and identification of horizontally transferred genes. Our barcode-based metagenome binning algori

SUBMITTER: Zhou F 

PROVIDER: S-EPMC2621371 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature