DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia.

ABSTRACT:

Background

DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk. Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology.

Methods

We investigated whether the DISC1 leu607phe polymorphism was associated with prefrontal gray matter volumes using magnetic resonance imaging in a cohort of patients with schizophrenia (N=19) and healthy volunteers (N=25) and positive and negative symptoms in 200 patients with schizophrenia.

Results

Among patients and healthy volunteers, phe carriers (N=

SUBMITTER: Szeszko PR 

PROVIDER: S-EPMC2623247 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature