Unknown

Dataset Information

0

Modeling and analyzing gene co-expression in hepatocellular carcinoma using actor-semiotic networks and centrality signatures.


ABSTRACT: Primary hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third most common cause of cancer mortality worldwide. Because of its high prevalence in developing nations, there have been numerous efforts made in the molecular characterization of primary HCC. However, a better understanding into the pathology of HCC required software-assisted network modeling and analysis. In this paper, the author presented his first attempt in exploring the biological implication of gene co-expression in HCC using actor-semiotic network modeling and analysis. The network was first constructed by integrating inter-actor relationships, e.g. gene co-expression, microRNA-to-gene, and protein interactions, with semiotic relationships, e.g. gene-to-Gene Ontology Process. Topological features that are highly discriminative of the HCC phenotype were identified by visual inspection. Finally, the author devised a graph signature-based analysis method to supplement the network exploration.

SUBMITTER: Fung DC 

PROVIDER: S-EPMC2623292 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

altmetric image

Publications

Modeling and analyzing gene co-expression in hepatocellular carcinoma using actor-semiotic networks and centrality signatures.

Fung David C Y DC  

Cancer informatics 20081105


Primary hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third most common cause of cancer mortality worldwide. Because of its high prevalence in developing nations, there have been numerous efforts made in the molecular characterization of primary HCC. However, a better understanding into the pathology of HCC required software-assisted network modeling and analysis. In this paper, the author presented his first attempt in exploring the biological implication  ...[more]

Similar Datasets

| S-EPMC5006023 | biostudies-literature
| S-EPMC5531524 | biostudies-other
| S-EPMC4079186 | biostudies-literature
| S-EPMC2707367 | biostudies-literature
| S-EPMC3835731 | biostudies-literature
| S-EPMC6368613 | biostudies-literature
| S-EPMC7244137 | biostudies-literature
| S-EPMC5310795 | biostudies-literature
| S-EPMC9239767 | biostudies-literature
| S-EPMC7609726 | biostudies-literature