Ontology highlight
ABSTRACT:
SUBMITTER: Dib-Hajj S
PROVIDER: S-EPMC26243 | biostudies-literature | 1996 Dec
REPOSITORIES: biostudies-literature
Dib-Hajj S S Black J A JA Felts P P Waxman S G SG
Proceedings of the National Academy of Sciences of the United States of America 19961201 25
Spinal sensory (dorsal root ganglion; DRG) neurons display slowly inactivating, tetrodotoxin-resistant (TTX-R), and rapidly inactivating, TTX-sensitive (TTX-S) Na currents. Attenuation of the TTX-R Na current and enhancement of TTX-S Na current have been demonstrated in cutaneous afferent DRG neurons in the adult rat after axotomy and may underlie abnormal bursting. We show here that steady-state levels of transcripts encoding the alpha-SNS subunit, which is associated with a slowly inactivating ...[more]