Evidence for gene-specific rather than transcription rate-dependent histone H3 exchange in yeast coding regions.

ABSTRACT: In eukaryotic organisms, histones are dynamically exchanged independently of DNA replication. Recent reports show that different coding regions differ in their amount of replication-independent histone H3 exchange. The current paradigm is that this histone exchange variability among coding regions is a consequence of transcription rate. Here we put forward the idea that this variability might be also modulated in a gene-specific manner independently of transcription rate. To that end, we study transcription rate-independent replication-independent coding region histone H3 exchange. We term such events relative exchange. Our genome-wide analysis shows conclusively that in yeast, relative exchange is a novel consistent feature of coding regions. Outside of replication, each coding region has

SUBMITTER: Gat-Viks I 

PROVIDER: S-EPMC2625437 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature