Ontology highlight
ABSTRACT:
SUBMITTER: Marcucci KT
PROVIDER: S-EPMC2626135 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Marcucci Katherine T KT Martina Yuri Y Harrison Frank F Wilson Carolyn A CA Salomon Daniel R DR
Virology 20080319 2
The porcine endogenous retrovirus (PERV) Gag protein contains two late (L) domain motifs, PPPY and P(F/S)AP. Using viral release assays we demonstrate that PPPY is the dominant L domain involved in PERV release. PFAP represents a novel retroviral L domain variant and is defined by abnormal viral assembly phenotypes visualized by electron microscopy and attenuation of early PERV release as measured by viral genomes. PSAP is functionally dominant over PFAP in early PERV release. PSAP virions are 3 ...[more]