Ontology highlight
ABSTRACT:
SUBMITTER: Lam MH
PROVIDER: S-EPMC2626285 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Lam Mandy H Y MH Urban-Grimal Danièle D Bugnicourt Amandine A Greenblatt Jack F JF Haguenauer-Tsapis Rosine R Emili Andrew A
PloS one 20090123 1
Protein ubiquitination is essential for many events linked to intracellular protein trafficking. We sought to elucidate the possible involvement of the S. cerevisiae deubiquitinating enzyme Ubp2 in transporter and receptor trafficking after we (this study) and others established that affinity purified Ubp2 interacts stably with the E3 ubiquitin ligase Rsp5 and the (ubiquitin associated) UBA domain containing protein Rup1. UBP2 interacts genetically with RSP5, while Rup1 facilitates the tethering ...[more]