Ontology highlight
ABSTRACT:
SUBMITTER: Cariappa A
PROVIDER: S-EPMC2626685 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Cariappa Annaiah A Takematsu Hiromu H Liu Haoyuan H Diaz Sandra S Haider Khaleda K Boboila Cristian C Kalloo Geetika G Connole Michelle M Shi Hai Ning HN Varki Nissi N Varki Ajit A Pillai Shiv S
The Journal of experimental medicine 20081222 1
We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of alpha2-6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposit ...[more]