Ontology highlight
ABSTRACT:
SUBMITTER: Stamataki Z
PROVIDER: S-EPMC2628366 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Stamataki Zania Z Shannon-Lowe Claire C Shaw Jean J Mutimer David D Rickinson Alan B AB Gordon John J Adams David H DH Balfe Peter P McKeating Jane A JA
Blood 20081006 3
Hepatitis C virus (HCV) primarily replicates within the liver, leading to hepatitis, fibrosis, and hepatocellular carcinoma. Infection is also associated with B-cell abnormalities, suggesting an association of the virus with B cells. The infectious JFH-1 strain of HCV can bind primary and immortalized B cells but fails to establish productive infection. However, B cell-associated virus readily infects hepatoma cells, showing an enhanced infectivity compared with extracellular virus. B cells expr ...[more]