Ontology highlight
ABSTRACT:
SUBMITTER: Cooley S
PROVIDER: S-EPMC2628378 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Cooley Sarah S Trachtenberg Elizabeth E Bergemann Tracy L TL Saeteurn Koy K Klein John J Le Chap T CT Marsh Steven G E SG Guethlein Lisbeth A LA Parham Peter P Miller Jeffrey S JS Weisdorf Daniel J DJ
Blood 20081022 3
Survival for patients with acute myeloid leukemia (AML) is limited by treatment-related mortality (TRM) and relapse after unrelated donor (URD) hematopoietic cell transplantation (HCT). Natural killer (NK)-cell alloreactivity, determined by donor killer-cell immunoglobulin-like receptors (KIRs) and recipient HLA, correlates with successful HCT for AML. Hypothesizing that donor KIR genotype (A/A: 2 A KIR haplotypes; B/x: at least 1 B haplotype) would affect outcomes, we genotyped donors and recip ...[more]