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ABSTRACT:
SUBMITTER: Furukawa T
PROVIDER: S-EPMC2628956 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Furukawa Tomoka T Wakabayashi Kanako K Tamura Ai A Nakagawa Hiroshi H Morishima Yoshihiro Y Osawa Yoichi Y Ishikawa Toshihisa T
Pharmaceutical research 20081029 2
<h4>Purpose</h4>Single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) transporter ABCG2 gene have been suggested to be a significant factor in patients' responses to medication and/or the risk of diseases. We aimed to evaluate the impact of the major non-synonymous SNP Q141K on lysosomal and proteasomal degradations.<h4>Methods</h4>ABCG2 WT and the Q141K variant were expressed in Flp-In-293 cells by using the Flp recombinase system. Their expression levels and cellular localiz ...[more]