Ontology highlight
ABSTRACT:
SUBMITTER: Zylka MJ
PROVIDER: S-EPMC2629077 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Zylka Mark J MJ Sowa Nathaniel A NA Taylor-Blake Bonnie B Twomey Margaret A MA Herrala Annakaisa A Voikar Vootele V Vihko Pirkko P
Neuron 20081001 1
Thiamine monophosphatase (TMPase, also known as fluoride-resistant acid phosphatase) is a classic histochemical marker of small-diameter dorsal root ganglia neurons. The molecular identity of TMPase is currently unknown. We found that TMPase is identical to the transmembrane isoform of prostatic acid phosphatase (PAP), an enzyme with unknown molecular and physiological functions. We then found that PAP knockout mice have normal acute pain sensitivity but enhanced sensitivity in chronic inflammat ...[more]