Unknown

Dataset Information

0

Population genetics of Trypanosoma brucei gambiense, the agent of sleeping sickness in Western Africa.


ABSTRACT: Human African trypanosomiasis, or sleeping sickness caused by Trypanosoma brucei gambiense, occurs in Western and Central Africa. T. brucei s.l. displays a huge diversity of adaptations and host specificities, and questions about its reproductive mode, dispersal abilities, and effective size remain under debate. We have investigated genetic variation at 8 microsatellite loci of T. b. gambiense strains isolated from human African trypanosomiasis patients in the Ivory Coast and Guinea, with the aim of knowing how genetic information was partitioned within and between individuals in both temporal and spatial scales. The results indicate that (i) migration of T. b. gambiense group 1 strains does not occur at the scale of West Africa, and that even at a finer scale (e.g., within Guinea) migration is restricted; (ii) effective population sizes of trypanosomes, as reflected by infected hosts, are probably higher than what the epidemiological surveys suggest; and (iii) T. b. gambiense group 1 is most likely a strictly clonally reproducing organism.

SUBMITTER: Koffi M 

PROVIDER: S-EPMC2629214 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Population genetics of Trypanosoma brucei gambiense, the agent of sleeping sickness in Western Africa.

Koffi Mathurin M   De Meeûs Thierry T   Bucheton Bruno B   Solano Philippe P   Camara Mamadou M   Kaba Dramane D   Cuny Gérard G   Ayala Francisco J FJ   Jamonneau Vincent V  

Proceedings of the National Academy of Sciences of the United States of America 20081223 1


Human African trypanosomiasis, or sleeping sickness caused by Trypanosoma brucei gambiense, occurs in Western and Central Africa. T. brucei s.l. displays a huge diversity of adaptations and host specificities, and questions about its reproductive mode, dispersal abilities, and effective size remain under debate. We have investigated genetic variation at 8 microsatellite loci of T. b. gambiense strains isolated from human African trypanosomiasis patients in the Ivory Coast and Guinea, with the ai  ...[more]

Similar Datasets

| S-EPMC3399808 | biostudies-literature
| S-EPMC2716717 | biostudies-literature
| S-EPMC3079580 | biostudies-literature
| S-EPMC1687208 | biostudies-literature
| S-EPMC4102443 | biostudies-literature
| S-EPMC3585011 | biostudies-literature
| S-EPMC4022266 | biostudies-literature
| S-EPMC4183442 | biostudies-literature
| S-EPMC3561069 | biostudies-literature
| S-EPMC122871 | biostudies-literature