Ontology highlight
ABSTRACT:
SUBMITTER: Usui K
PROVIDER: S-EPMC2629283 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Usui Kazuya K Goldstone Claire C Gibert Jean-Michel JM Simpson Pat P
Proceedings of the National Academy of Sciences of the United States of America 20081222 51
The thoracic bristle pattern of Drosophila results from the spatially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by the activity of many discrete cis-regulatory sequences. However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-regulatory elements, allows the development of bristles positioned at wild-type locations. We demonstrate that the p ...[more]