Ontology highlight
ABSTRACT:
SUBMITTER: Gokel GW
PROVIDER: S-EPMC2629643 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Coordination chemistry reviews 20080401 8-9
Hydraphiles are synthetic ionophores that were designed to mimic some properties of protein channels that conduct such cations as sodium. They use macrocyclic (crown) polyethers as amphiphilic headgroups and as entry and exit portals. Their overall length is controlled by covalent links between the two headgroups (distal macrocycles) and the "central relay" unit, typically also an azacrown. The hydraphiles insert in the bilayer membranes of synthetic phospholipid vesicles or vital cells and medi ...[more]